Lieberman Lab· Notre Dame Chemistry & Biochemistry

Test Strip Lot Checking Program

Drug test strips help prevent drug overdoses. People can use these strips anywhere, and studies show the results actually change behavior — people report not using, using less, or using in ways that are less likely to cause overdose, like with someone nearby (Goldman et al., 2019). Because they are such a valuable tool, it is critical that they work right.

Choose a target · 2 live · 4 planned
Fentanyl Live
Single-molecule detection at 200 ng/mL. Seven-substance interference panel built around common cuts and adulterants.
36 lots 102 submissions 80.8% detect fentanyl in DI water
Open dashboard →
Xylazine Live
Two concentrations, two water sources — isolates the effect of hard tap water. Eleven-substance panel led by other alpha-2 agonists.
20 lots 73 submissions 73% clearly detect xylazine in DI water 70% clearly detect xylazine in tap water 35% give a faint, inconclusive line
Open dashboard →
Medetomidine Planned
Veterinary alpha-2 agonist increasingly found alongside xylazine in the supply.
Not yet built
Benzodiazepines Planned
Multi-molecule — several common analogs tested as separate model compounds, not one target.
Not yet built
Nitazenes Planned
Multi-molecule, like benzodiazepines — several structurally distinct nitazene analogs in circulation.
Not yet built
Multi-target strips Planned
Strips that screen for more than one drug class at once — a lot's identity can span more than one dashboard.
Not yet built

What we’ve found so far

What we checked

We tested 36 batches of fentanyl strips from 20 companies and 20 batches of xylazine strips from 10 companies. Lab members have sent in 175 test reports so far.

How they did

Most of the time, the strips worked. In plain water, fentanyl strips were right 99.7% of the time. When fentanyl was there, they found it about 8 in 10 times.

Xylazine strips gave a clear answer in about 7 of 10 tests. About 35% of tests gave a faint line that was too hard to call.

Two limits worth knowing about

Even so, 16 of the 36 fentanyl batches found fentanyl every time and never gave a false alarm in plain water.

Methodology & limitations
Why we test, what we test, what "brand" vs "lot" means, and where the limits of this testing are.
Read the deeper dive →

Send us strips, or flag something we should test

Lab tools · for lab members
Lot checking progress tracker
Which test-strip lots are in the lab and how much testing each one still needs, by brand and lot — plus a "be on the lookout" list of brands to purchase.
78 lots tracked 7 fully tested 6 on the lookout
Open tracker →
Log a new lot
Received a new brand or lot in the lab? Log it here so it shows up on the progress tracker — or flag a brand/lot we should be on the lookout for. Restricted to lab members with access.
Open the form →